Endomysium Antibodies Detection with Umbilical Cord Sections.
نویسنده
چکیده
Anti-Endomysium antibodies (EmA) detection is the most reliable test for the diagnosis of coeliac disease. Usually monkey distal oesophagus sections are used. Tests with ELISA anti-gliadin (AGA) antibodies show that umbilical cord EmA tests can effectively substitute monkey oesophagus EmA tests.
منابع مشابه
Anti-endomysium antibodies detection in the celiac disease screening: Indirect immunofluorescence pattern using umbilical cord sections as substrate.
Celiac disease screening test with anti-endomysial antibodies detection is limited by the use of endangered species tissue (monkey distal oesophagus) as well as by the high costs of commercial kits. Due to such limitations new tests are developed to avoid the use of monkey tissue: an IFA test utilising umbilical cord sections (a discarded tissue) and an ELISA test detecting anti-transglutaminas...
متن کاملEndomysium antibodies in coeliac disease: an improved method.
The ultra structural binding sites of endomysium antibodies have been studied on human umbilical cord tissue. The sensitivity and specificity of IgA endomysium antibodies were compared with recently described methods using basement membrane of smooth muscle of monkey oesophagus. Thirty adults affected by coeliac disease (10 in remission) and 75 healthy adult controls with normal intestinal muco...
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Background and aims: Coeliac disease (CD) is a multifactorial disorder which has an autoimmune component characterised by the occurrence of disease specific autoreactive antibodies against the enzyme tissue transglutaminase (tTG). The aim of this study was to investigate whether binding of antibodies to the enzyme influences tTG activity. Methods: tTG activity was assayed in the presence of imm...
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ورودعنوان ژورنال:
- ALTEX
دوره 14 1 شماره
صفحات -
تاریخ انتشار 1997